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domingo, agosto 30, 2009



Aqui un resumen de este medicamento que su utiliza por algunos medicos para el tratamiento de la Hipertension Pulmonar.

En farmacología, la nifedipina es un bloqueador de canales de calcio del tipo dihidropiridina, usado en medicina para el alivio de la angina de pecho, en especial la angina de Prinzmetal, así como para la hipertensión arterial. Otros usos clínicos de la nifedipina incluyen la terapia del fenómeno de Raynaud, nacimientos prematuros y los espasmos dolorosos del esófago en pacientes con cáncer y tétano. A menudo se emplea para el grupo de pacientes con hipertensión pulmonar cuyos síntomas responden a los bloqueadores de los canales de calcio.

La nifedipina disminuye la tensión arterial, aunque en causan muy frecuentemente vértigo y desmayos en las primeras dosis. La taquicardia puede también aparecer como una reacción secundaria. Para evitar estos malestares, se han diseñado preparaciones especiales como las de liberación sostenida o de liberación osmótica gastrointestinal continua, usados para pacientes con hipertensión y angina.
El metabolismo de la nifedipina, llamada también nifedipino en México, depende de un citocromo .
Este el mas abundante en el organismo.
Tanto en el hígado como en el tracto gastrointestinal.
La nifedipina se utilizo en su caracterizacion.

Otro aspecto interesante es la interacción con el jugo de toronja (hispanohablantes: ¡no confundir con jugo de uva!).

Este jugo hace que los niveles de nifedipina se eleven a casi el doble, pero esta interación fue descubierta con el analogo felodipina.
El metabolismo de fármacos como este varia de una población a otra. Por lo que numerosos estudios realizados con nifedipina en japoneses, chinos, indios, holandeses, alemanes, ingleses y mexicanos llevó a extender las expericias observadas , que resultó ser un citocromo muy particular. Pero ahora en lugar de nifedipina se prefiere utilizar al midazolam como fármaco.

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